MWC, GMWC (Generalized MWC Arrows) Reference Home

GMWC[kcat,n,c,L,K] is an uninstantiated function that encapsulates the parameters used in the Generalized Monod-Wyman-Changeux Model.

The functions MWC and GMWC can be use interchangeably, however, it is recommended for notebook clarity that MWC be used when the traditional model is used and GMWC be used when the generalized model is used.

Traditional MWC

Single Substrate

Multple Substrates

Generalized MWC

Without Competitive Inhibition

With a Single Substrate
With Multiple Substrates

With Competitive Inhibition

[1] Monod J, Wyman J, Changeux JP (1965) On the nature of allosteric transitions: A plausible model. Journal of Molecular Biology, 12:88.
[2] Najdi TS, Yang CR, Shapiro BE, Hatfield GW, Mjolsness ED (2006) Application of a generalize MWC model for the mathematical simulation of pathways regulated by allosteric enzymes. Journal of Bioinformatics and Computational Biology, in press.

[rev: 18 July 2012]